It was first called Calle de Nuestra Señora de la Bendición
Don Baltasar de Soriano, high employee of the Real Hacienda lived in one of its houses with his daughter hija María de Encarnación. Don Juan Pérez
de Guzmán was named governor of Cartagena in 1658 and fell in love with the girl. Pérez de Guzmán asked for her hand in marriage but the wedding wasn't carried on.
Later, he was named Governor of Puerto Rico and fled to the island on the first galleon that set sail without informing anyone in the family. When María de Encarnación found out about her fiance's departure, in great pain she strangled herself with the silk mantilla she used to attend mass on Sundays. The vile boyfriend apart form running out on her, left her pregnant. Since then the street was named of the Mantilla.